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KMID : 0371319740160120005
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Journal of the Korean Surgical Society
1974 Volume.16 No. 12 p.5 ~ p.16
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Multiple Familial Colonie Polyposis in Brothers
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진수일/Chin, S.Y.
오수명/김용일/노재윤/김병수/이상료/Oh, S.M./Kim, Y.I./Ro, J.Y./Kim, B.S./Lee, S.R.
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Abstract
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Multiple familial colonic polyposis, a rare condition, is transmitted as a dominant gene according .to the Mendelian laws of inheritance. The sexes are equally, and the gene is transmitted by both male and female, but only by affected members of a family. Goligher (1961) has described mulitiple familial colonic polyposis as the most clearly defined..precancerous lesion known in medicine. Symtpoms only occur once polyps have developed. They usually make their appearance in the twenties, and rare under the age of 10, and it is exceptionally rare for symptoms first to appear after the age of 40.
Diagnosis of familial colonic polyposis depends on histological confirmation of adenomatous polyps, together with an appropriate family history.
Multiple familial colonic polyposis is attended by higher incidence of eventual carcinoma than are most benign processes. If untreated patients were to survive a sufficient number of years, it has been surmised by some that the eventual incidence of carcinoma would be 100 percent.
No report has appeared in Korean literature.
Recent we have experienced two cases of multiple familial colonic polyposis in brothers. A reiew of literature was made.
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